3 common strategies:
 
3 common strategies:
*Alteration of extracellular growth signals
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**While most soluble mitogenic growth factors are made by one cell type to stimulate another ('''heterotypic signaling'''), cancer cells can synthesize the growth factors to which they are responsive - ''positive feedback loop'' or '''autocrine stimulation''' - and obviates dependence on GFs from other cells within the tissue.
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